Molecular details of protein reveal glimpse into how kidney stones form

Penn study shows that 3D structure of ion channel protein could inform drug discovery UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE PHILADELPHIA – Kidney stones–solid, pebble-like grit that forms when too much of certain minerals like calcium are in the urine–can strike men, […]

Clues to lupus’s autoimmune origins in precursor cells

DN2 B cells expanded in SLE patients EMORY HEALTH SCIENCES In the autoimmune disease systemic lupus erythematosus or SLE, the immune system produces antibodies against parts of the body itself. How cells that produce those antibodies escape the normal “checks and […]

No ‘reservoir’: detectable HIV-1 in treated human liver cells found to be inert

Novel study suggests HIV-1 still detectable in human liver macrophages unlikely to stay infectious after long-term antiretroviral therapy JOHNS HOPKINS MEDICINE In a proof-of-principle study, researchers at Johns Hopkins report that a certain liver immune cell called a macrophage contains […]

Phage therapy draws renewed interest to combat drug-resistant microbes

The married professors were spending their Thanksgiving holiday in Egypt when the husband, Thomas L. Patterson, Ph.D., got very sick very quickly, experiencing fever, nausea and a racing heartbeat. By the time Patterson was accurately diagnosed with a highly multi-drug […]

The ‘dynamic duo’ of enzymes in the development of cancer

Mutated helicase enzymes shown to work together to disrupt telomere homeostasis and regulation of cell division. All strands of DNA have a non-coding region at the end of the strand known as the telomere. During each replication of the gene, when the […]

Analysis reveals genomic effects of a new cancer treatment now in clinical trials

PHILADELPHIA -A twist on the molecular mechanism of how a new cancer drug works could aid in better identifying the best treatments for patients for an array of cancers. The finding is described in Molecular Cell in a study led by Eric […]

Study overturns what we know about kidney stones

Current treatments for kidney stones are limited and sometimes painful. Research is changing what we thought we knew about their composition and behavior, suggesting that one day, we may fully dissolve them “right in the patient’s kidney.” In the United States, an […]

Nanoparticle therapeutic restores function of tumor suppressor in prostate cancer

Think of it as a cancer therapy zag instead of a zig. While many groups are developing cancer therapies to target proteins and pathways that are highly active in cancer cells, a team of investigators from Brigham and Women’s Hospital […]

Extraordinary Case: 4 People Get Cancer From Donated Organs

There are rare instances wherein organ donors unwittingly pass infectious diseases to the organ recipients, but an even rarer occurrence is passing cancer through the transplant. In Europe, four people who received organs from a single donor develop breast cancer […]

Dangerous blood pressure spikes among blacks happen five times more often than average

Black adults experience dangerous spikes in high blood pressure, called a hypertensive crisis, at a rate that is five times the national average, according to a study presented at the American Heart Association’s Joint Hypertension 2018 Scientific Sessions, an annual […]