Chronic diseases driven by metabolic dysfunction

New model suggests natural healing cycle becomes blocked by cellular miscommunication, allowing conditions like cancer, diabetes and some neurological disorders to persist; a small but dramatic autism trial offers evidence UNIVERSITY OF CALIFORNIA – SAN DIEGO IMAGE: THIS IS A FALSE-COLOR […]

Miniaturized HTS assay identifies selective modulators of GPR119 to treat type 2 diabetes

A novel high throughput screening (HTS) assay compatible with an ion channel biosensor component was used successfully to identify selective and active small molecule modulators of G protein-coupled receptor 119 (GPR119), a promising target for the treatment of type 2 […]

New test uncovers metabolic vulnerabilities in kidney cancer

DALLAS – Aug. 28, 2018 – In order to halt the growth of cancer cells, you have to know what feeds them. Researchers at the nationally recognized Kidney Cancer Program at UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center have developed a novel approach using glucose that […]

Study provides new insights for ways to use cell metabolism to treat cancer

UNIVERSITY OF CINCINNATI ACADEMIC HEALTH CENTER CINCINNATI–Researchers at the University of Cincinnati (UC) College of Medicine have discovered that cell metabolism plays an important role in the ability of cells to start a survival program called autophagy, an unwanted side effect […]

The natural sugar that reduces the risk of diabetes in mice

Sugar may be the villain of our time, with too much of the sweet stuff known to be a leading cause of developing diabetes. But now researchers at Washington University School of Medicine in St. Louis have discovered a new way to […]

Powerful molecules provide new findings about Huntington’s disease

LUND UNIVERSITY Researchers at Lund University in Sweden have discovered a direct link between the protein aggregation in nerve cells that is typical for neurodegenerative diseases, and the regulation of gene expression in Huntington’s disease. The results pave the way for […]

New antibiotic candidates were inside us all along

With bacteria rapidly evolving resistance to our best antibiotics, scientists are searching high and low for new ones. In recent years promising drug candidates have turned up in some unexpected places, like rattlesnake venom, platypus milk, and tobacco flowers – and now, already inside the human […]

Receptor protein in the brain controls the body’s fat ‘rheostat’

Scientists at the University of Michigan and Vanderbilt University have identified the function of a protein that has been confounding metabolism researchers for more than two decades. And it may have implications both for treating obesity and for understanding weight gain during […]

Natural sugar defends against metabolic syndrome, in mice

New research, in mice, indicates that a natural sugar called trehalose blocks glucose from the liver and activates a gene that boosts insulin sensitivity, reducing the chance of developing diabetes. Activating the gene also triggers an increase in calories burned, reduces […]